All About Alpha-Lipoic Acid

Alpha-lipoic acid (ALA) occurs naturally in the body and plays a crucial role in the energy-producing structures of cells. At the molecular level, it binds to protein and functions as a cofactor for several important mitochondrial enzymes. Although the majority of alpha-lipoic acid produced by the body is used almost entirely to generate energy, researchers have found that ALA may act as an antioxidant when incorporated into the diet.

Taken in supplement form, alpha-lipoic acid may defend the body against free radicals and single action molecules which can damage cells and lead to degenerative disorders associated with diminished health and aging. Other common and scientific names for alpha-lipoic acid include ALA, biletan, lipoic acid, lipoicin, thioctacid, thioctan and thioctic acid.

Sources of alpha-lipoic acid

Alpha-lipoic acid is synthesized in both animals and humans. But because little “free” alpha-lipoic acid is left circulating in the body after cells use it for energy, external sources of ALA are needed to produce an antioxidant effect. These include meats and select vegetables (such as spinach) and dietary supplements that contain alpha-lipoic acid.

How ALA works in the body

Alpha-lipoic acid, recognized for its antioxidant potential in the late 1980s, is said to function in both reduced and oxidized forms. It may neutralize free radicals in both the watery and fatty regions of cells and fortify the antioxidant power of vitamins C (water soluble) and E (fat soluble). It’s also been said to extend the metabolic lifespan of glutathione (a tripeptide essential to the metabolism of nutrients in cells and one that plays a major role in dissolving toxic substances in the liver) and coenzyme Q10 (a vitamin-like enzymatic cofactor needed for cells to produce energy). Supplemental forms of alpha-lipoic acid are easily absorbed into the bloodstream and may cross the blood-brain barrier.

Alpha-lipoic acid benefits; claims

Research indicates that ALA supplementation may slow age-related heart problems and brain degeneration, and help boost the physiological strength and cognitive function of older persons – hence its reference as an anti-aging nutrient. ALA may also stave off age-related macular degeneration and, when added to cosmetic creams and face masks, alpha-lipoic acid may enhance the elasticity and youthful appearance of skin.

Benefits of ALA supplementation may include:

o A reduction of oxidative stress and circulating free radicals in the body

o Improved heart and artery health

o Enhanced immune system strength and brain function

o Blood glucose regulation and balanced cholesterol

o Detoxification of the liver

o A healthy neural system

Alpha-lipoic acid side effects, safety and toxicity

Alpha-lipoic acid is said to be safe in doses ranging from 100 mg to 400 mg daily.* It may also be toxic, and even fatal, in doses as high as 1,800 mg a day.* Excessive doses of alpha-lipoic acid have been known to cause stomach upset and nausea and may lead to dangerously low blood glucose levels. The frequency and strength of ALA supplementation is typically based on the reason for treatment.

It is advisable to consult a physician prior to ALA supplementation if you’re:

o Taking any type of prescription medicine

o Allergic to any prescription or over-the-counter medicine or dietary supplement

o Pregnant or plan to become pregnant

o Nursing

o Suffering from any type of cardiovascular, heart, blood or arterial disorder

Though alpha-lipoic acid appears to be safe, the effects of long-term use have yet to be fully explored. Contraindications may exist, as might adverse reactions with certain medications or supplement regimens.

Research shows that the potency of alpha-lipoic acid may be diminished if mixed with certain compounds such as thiamine.

*Statement not evaluated by FDA

Clinical studies and alpha-lipoic acid research

The majority of current research available focuses on the impact of alpha-lipoic acid on rodents in the laboratory. ALA research has found that alpha-lipoic acid supplementation may aid inflammation in rats and reduce oxidative stress. It may also help to metabolize glucose and regulate blood sugar in mice.

Because oxidative damage is shown to be a major factor in the decline of physiological function in older persons, ALA’s potential in fighting immune disorders may be far reaching, as ALA has been found to protect cells from oxidative damage in older rats. It’s also been shown to suppress collagen-induced arthritis in mice and to slow retinal degeneration. Rodent studies suggest that ALA may improve epidermal blood flow and aid nerve damage caused by high blood glucose.

As a result of aggressive testing in the lab, alpha-lipoic acid is being studied for its potential in fighting human disorders as the cellular level. Alpha-lipoic acid research, however, is in the nascent stage, and the long-term potential of ALA supplementation in human health is relatively unknown.

Alpha-lipoic acid efficacy and the FDA

ALA is considered a dietary supplement in the U.S. and is neither regulated nor inspected by the FDA. As a result, there’s no guarantee to the purity, safety or strength of alpha-lipoic acid supplements. Research has revealed ALA benefits in rodents, but effective human clinical studies remain in the distance.

Laboratory tests in 2007 found that certain ALA supplements contained less alpha-lipoic acid than indicated on the label.

For more information on Alpha Lipoic Acid, visit www.VitaCost.com/Supplements/Alpha-Lipoic-Acid-ALA

References

1. All About alpha-lipoic acid. Frequently asked questions. The Complementary and Alternative Medicine Information Source Book. Edition 1, 2001 p159.

2. [alpha ]-Lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats.(Author abstract)(Report) Meltem Kolgazi, Nermina Jahovic, Meral Yuksel, Feriha Ercan, Lnci Alican. Journal of Gastroenterology and Hepatology. Nov 2007 v22 i11 p1859 (7).

3. Antioxidants and narrow band-UVB in the treatment of vitiligo: a double-blind placebo controlled trial. (Author abstract)(Report) Clinical and Experimental Dermatology. Nov 2007 v32 i6 p631 (6).

4. The effect of [alpha ]-lipoic acid on symptoms and skin blood flow in diabetic neuropathy.(Author abstract)(Report) H.Y. Jin, S.J. Joung, J.H. Park, H.S. Baek, T.S. Park. Diabetic Medicine. Sept 2007 v24 i9 p1034(5).

5. Mitochondrial Aging and the Beneficial Role of [alpha]-Lipoic Acid. (Author abstract) A. R. Palaniappan, A. Dai. Neurochemical Research. Sept 2007 v32 i9 p1552 (7).

6. Wellness Guide to Dietary Supplements. UC Berkeley wellnessletter.com. 2007.

7. New alpha-lipoic acid from Aquanova Nutraceuticals International. July 2007 pNA.

8. ConsumerLab.com tests alpha lipoic acid supplements Nutraceuticals World. July-August 2007 v10 i7 p14 (1).

9. Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice. Eun Young Lee, Chang-Keun Lee, Ki-Up Lee, Joong Yeol Park, Kyung-Ja Cho, You Sook Cho, Hee Ran Lee, Se Hwan Moon, Hee-Bom Moon, Bin Yoo. Rheumatology International. Jan 2007 v27 i3 p225 (9).

10. Alpha-lipoic acid. Alternative Medicine Review. Sept 2006 v11 i3 p232 (6).

Cold Sore Medicine Review – Abreva

You can find Abreva Cold Sore Treatment over-the-counter at most any pharmacy aisle in any store. Abreva is approved by the FDA and says it will reduce the healing time for a cold sore or fever blister. The question is, does it work? We will take a look in a minute.

The Abreva product comes in a relatively tiny 2 gram tube. You can find it retailing for approximately $15 in all stores, or through the Internet.

In reading the directions, it states that you should put the medicine directly on the area where you feel the cold sore coming on. You’re to do this 5 times throughout the day. Abreva says that the key is to begin treatment before the cold sore actually breaks out.

As someone who has cold sores a couple of times during the year, I know how tough they can be to deal with, especially after breaking out. So, I’m always looking for a cold sore medicine that works. With that said, here is my review of Abreva.

1. I found myself having some trouble getting the package open. There is no way to get it open without scissors. Then, when you do get to it, the tube is very tiny, leaving you to wonder if there is anything in it.

2. I found that Abreva took almost a week to take away my pain, not a few days that the product claims. I must say, prescription cold sore medicine is much faster working.

3. Abreva Cold Sore Treatment didn’t eliminate my cold sore quickly. It did work, but not as well as other cold sore medications I’ve used in the past, and nowhere near as fast as a prescription.

4. I was out of Abreva after only 10 days of use. I used it exactly as the directions stated, but the tube didn’t last long. I was a little disappointed to say the least.

I have talked with others who have had good luck with Abreva, but I’m not in that group. I can’t give Abreva a high rating compared to other cold sore medicines available.

Copyright 2006 – Terry Edwards. All Rights Reserved Worldwide. Reprint Rights: You may reprint this article as long as you leave all of the links active and do not edit the article in any way.

Reviews on Acai Berry – How to Lose Your Extra Pounds With Acai Berry

Acai berry is a great supplement which helps you in reducing weight very easily. As a matter of fact, it has been endorsed as the super food, but renowned celebrities, who have been benefited immensely from it. The best thing about Acai fruit is that it is completely natural and you can easily eat it without getting scared of any side effects. There are great reviews on Acai berry over the internet because the product has proven to be very successful for people who were trying to get rid of those extra pounds but had lost all hopes.

Reviews on Acai berry are very positive and helps other people to take the initiative as well. The product increases the energy levels and enhances the immune system so that you become healthier and lose all the extra fats in your body. The product also helps in curbing your hunger and reduces your appetite with the high availability of fiber and good calories. These pills are extremely effective and being used by people with great confidence all over the globe.

The main ingredient in Acai berry is called anthocyanin which is also available in red wine. It makes you stronger and helps you to reduce weight without putting in the effort. Reviews on Acai berry also claims that it slows down the aging process and relives join pain. Another great feature of this fruit supplements is that it not only makes you lose weight but also makes sure that your body is in good shape. You don’t get this surety with other medicines which you use to lose weight. Although they make you lose weight but internally you tend to lose all your body power and immune system.

Reviews on Acai berry products are seen as a plus sign for the product. There are great many fans all over the world who admire the effectiveness of Acai berry supplements. If you are also interested in cutting down some kgs then you must get your hands on these effective pills. They would make sure that you lose weight in the healthiest way without effecting your heart and immune system. All of the factors have contributed greatly to the success of this products. If you want to buy the products online then look for sellers that offer free bottles and trials for free. This way you would be able to get the most reliable supplier over the internet.